Oral submucous fibrosis osf is a premalignant condition caused by betel chewing. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients. A link between scleroderma and oral submucous fibrosis has also been suspected on the basis of similarity of histological characteristics tsai et al, 1999. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. Oral submucous fibrosis osmf is also called as diffuse oral submucous fibrosis, idiopathic scleroderma of mouth, idiopathic palatal fibrosis, sclerosing stomatitis, juxta epithelial fibrosis, etc. These are injected into the fibrotic bands weekly for 68 weeks with regular monitoring of mouth opening.
The documents contained in this web site are presented for information purposes only. The habit is prevalent in south asian populations but has been recognized nowadays also in europe and north america. Oral submucous fibrosis osf is a potentially malignant, chronic, progressive disorder seen mostly in people from asia, where the habit of betel chewing is frequently practiced. Curcumin has some important biological properties such as anti. A 33yearold pakistani female with submucous fibrosis exhibited a progressive stiffness of the oral mucosa, trismus, and difficulty in opening her mouth, vesicle formation, loss of normal tongue. Introduction oral submucous fibrosis was first illustrated by schwartz in 1952 as idiopathic tropica mucosae oris, but joshi was the one who subsequently gave it the present term. The aim of this study was to compare cystatin c expression in normal human buccal mucosa and oral submucous fibrosis osf specimens and further explore the potential mechanism that may lead to induction of cystatin c expression. Oral submucous fibrosis osmf is a disease of unknown etiology. A sectional splint for maintaining surgically enhanced vertical height in an oral submucous fibrosis patient. Oral submucous fibrosis osmf, oral fibrosis introduction oral submucous fibrosis is a chronic disease of insidious onset featuring the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx and esophagus. Use of buccal fat pad for treatment of oral submucous fibrosis. Oral submucous fibrosis was first illustrated by schwartz in 1952 as idiopathic tropica mucosae oris, but joshi was the one who subsequently gave it the present term.
Intraoperative consultation upper aerodigestive tract ioc. Oral submucous fibrosis osf is a highrisk precancerous condition of the oral cavity. Oral submucous fibrosis results in marked rigidity and an eventual inability to open the mouth. After the 10year intervention,11 new cases of oral.
Interventions for the management of oral submucous. Jun 18, 2018 oral submucous fibrosis is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues lamina propria and deeper connective tissues. Most patients, however, seek medical attention when the disease has become moderate to severe. Acofs original study vol i issue vi application oflasers for. This article is from journal of clinical and experimental dentistry, volume 6. Histologically, osf is characterized by epithelial atrophy and progressive accumulation of.
Unusual complication of intralesional corticosteroid in oral. It is a potentially malignant disorder pmd and crippling condition of oral mucosa. Increased copper level in oral mucosal tissue of patients. Lipid profile in oral submucous fibrosis lipids in. Thapliyal, mds, fiboms, ramen sinha, mds, fiboms, and p. Oral submucous fibrosis osf is a chronic disease of the oral mucosa characterized by inflammation and a progressive fibrosis of the lamina propria and deeper connective tissues.
Studies on the natural history of oral submucous fibrosis osf show that it is an insidious fibrotic disorder affecting the entire oral mucosa that progresses with time. Oral submucous fibrosis osf is one of the wellrecognized oral potentially malignant disorders. Proteomic identification of cyclophilin a as a potential. Submucous fibrosis is an insidious, chronic disease affecting any part of the oral cavity and sometimes the pharynx. Oral submucous fibrosis osmf is a chronic, progressive disease that alters the. Correlation of histopathological diagnosis with habits and clinical. Prosthodontic rehabilitation of an edentulous patient. Evaluation of ki67 expression in oral submucous fibrosis and its correlation with.
Proteomic identification of cyclophilin a as a potential biomarker and therapeutic target in oral submucous fibrosis yao yuan, xiaohui hou, hui feng, rui liu, hao xu, wang gong, jing deng. Myofibroblasts in stroma of oral submucous fibrosis. Areca nut chewing is its key etiologic factor, but the full pathogenesis is still obscure. Classification system for oral submucous fibrosis chandramani bhagvan more, swati gupta, jigar joshi, saurabh n varma abstract oral submucous fibrosis osmf is a potentially malignant disorder pmd and crippling condition of oral mucosa. Jun 18, 2018 in 1952, schwartz coined the term atrophica idiopathica mucosa oris to describe an oral fibrosing disease he discovered in 5 indian women from kenya. This paper tells the aetiology, clinical presentation and treatment. Involvement in the pathogenesis of oral submucous fibrosis chengchia yu1,2,3, chunghung tsai4,5, hsini hsu1, yu. Conclusions there are few highquality studies available and the present. The rationale of using exfoliative cytology in our study lies in the epithelial physiology where continuous exfoliation of. Oral submucous fibrosis osf is a chronic and potentially malignant. Fact sheet on oral submucous fibrosis cansa the cancer.
Oral submucous fibrosis is a common oral health problem in india. Involvement in the pathogenesis of oral submucous fibrosis. The oral submucous fibrosis osmf has been managed earlier by various medical and surgical modalities but none of these methods is found to give relief to these patients. Definition it is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx. A retrospective study, int oral health, 7, 2015, 8285. A sectional splint for maintaining surgically enhanced. Get a printable copy pdf file of the complete article 504k, or click on a page image below to browse page by page. Compared to traditional betel quid, gutkha chewing tends to begin at a younger age and has a shorter time to the development of disease, so cases of oral submucous fibrosis have been seen as young as 11 years of age. Oral submucous fibrosis osmf is a potentially malignant. Patients are advised to do mouthopening exercises, for example, by placing ice. Oral submucous fibrosis osmf is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is believed.
It is a chronic progressive disorder and its clinical presentation depends on the stage of the disease at detection. Mantri t, thete sg, male v, yadav r, grover i, adsure gr, kulkarni d. Jul 01, 20 oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Oral submucous fibrosis an overview sciencedirect topics. Study of the role of salivary lactate dehydrogenase in habitual tobacco chewers, oral submucous fibrosis and. Original article introduction oral submucous fibrosis osmf is a potential malignant disorder of oral. Dental college, hospital and research institute, india introduction oral submucous fibrosis was first described by schwartz in 1952 among five indian females living in kenya and he coined.
Oral submucous fibrosis osf is a chronic, progressive, scarring and potentially malignant disease of the oral mucosa seen primarily in the indian subcontinent and in south east asia. Oral submucous fibrosis is a high risk precancerous lesion which predominantly affects indians, indians in diasporas, to a lesser extent in other asiatic, and sporadically in europeans. Matrix metalloproteinases mmps are enzymes that degrade all the components of extra cellular matrix and collagen. Reader, 1senior lecturer, 2post graduate student, department of oral pathology and microbiology, bhojia dental college and hospital, bhud, baddi, dist. Oral submucous fibrosis osf, first described in the early 1950s, is a potentially malignant disease predominantly seen in people of asian decent.
Oral submucous fibrosis can be seen at any age except for young children. It is very common in southeast asia but has started. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Oral submucous fibrosis osf, is a wellrecognized, oral potentially. Here we are presenting two cases of oral submucous fibrosis showing malignant potential and development of oral squamous cell carcinoma. A total of 96 patients with oral submucous fibrosis have received four regimens of treatmentlocal dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. The disease is rare in north america, and most cases seen in migrants from south east asia or india.
Increased copper level in oral mucosal tissue of patients with submucous fibrosis and who chew areca nut products the editor, sir, oral submucous fibrosis osmf is a crippling disease that. Cyclophilin a was revealed as a candidate marker for human. Yao yuan, xiaohui hou, hui feng, rui liu, hao xu, wang gong, jing deng, chongkui sun, yijun gao, jieying peng, yingfang wu. Pdf a case reporting oral submucous fibrosis researchgate. There is a need for highquality rct in this area, especially. If the disease is detected at a very early stage, cessation of the habit is sufficient. The disease is rare in north america, and most cases seen in. Osmf is characterized by deposition of dense collagen. Pdf oral submucous fibrosis osf is a premalignant condition caused by betel chewing. Background oral submucous fibrosis is a chronic debilitating disease of oral mucosa and is characterized by generalized fibrosis of the oral soft tissues which tends to present itself clinically as palpable vertical fibrous bands. Lack of reliable evidence for oral submucous fibrosis treatments abstracted from fedorowicz z, chan shihyen e, dorri m, nasser m, newton t, shi l. Quantitative proteomic analysis for novel biomarkers of. Oral sub mucous fibrosis is a crippling disease of mouth with high malignant potential that has high prevalence rate in india and south east asia.
Submucous fibrosis appendix p 4 results in bad oral hygiene. Background oral submucous fibrosis is a common oral health problem. Sri lanka journal of medicine is the official journal of the kandy society of medicine. Oral submucous fibrosis osf is a chronic and insidious lesion of oral mucosa which demonstrates particularly prevalent in some south and southeast asian countries 1, 2. Deepti garg jindal, reader, department of oral pathology and. Prevalence and distribution of oral mucosal lesions. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common. Fibroblastic phenotype in oral submucous fibrosis a cell culture analysis abhishek banerjee1, v. Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis jasdeep kaur, and reinhilde jacobs omfsimpath research group, department of imaging and.
Please stop the habit of gutkha or betel nut chewing if you have. Pdf autofluorescence spectroscopy of betel quid chewers. Oral submucous fibrosis osmf is a chronic disease of insidious onset and a prevailing potentially malignant disorder characterized by juxtaepithelial inflammatory reaction along with mucosal fibrosis. Use the qr code scanner to access this article online in our databse article code. Mar 12, 2020 when oral submucous fibrosis is detected in its early stages, ceasing to consume the irritating agent, such as the areca nut used in betel quids or chewing tobacco, will often resolve the problem. Oral submucous fibrosis is a chronic, complex, premalignant 1% transformation risk condition of the oral cavity, characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of the submucosal tissues the lamina propria and deeper connective tissues. Oral submucous fibrosis osmf is a chronic disorder seen only in persons who chew betel areca catechu nuts, pan masala or gutkha and is characterized by tightening of the buccal, and sometimes palatal and lingual mucosae, causing trismus. It is a chronic insidious scarring disease of oral cavity, pharynx and. Discovery of novel biomarkers in oral submucous fibrosis. Oral submucous fibrosis osmf is a chronic, insidious, disabling disease involving oral mucosa the oropharynx, and rarely the larynx. The underlying muscles of mastication may be affected resulting in trismus and disability. Pdf a case of oral submucous fibrosis occurring in a 38 year old man is presented. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options.
Curcumin is the active component of turmeric which is a south asian spice commonly used for cooking. Curcumin is the active component of turmeric which. Oral submucous fibrosis osf is a precancerous condition associated with the use of areca nut in various forms. Oral submucous fibrosis osf is a chronic pathological condition which is predisposes to oral cancer. It is very common in southeast asia but has started to spread to europe and north america. Oral submucous fibrosis osf is a premalignant disorder associated with the chewing of areca nut betel nut. Worldwide estimates of oral submucous fibrosis osmf show a confinement to. It is a premalignant condition and has been on a constant rise either due to an increase in the habitual chewing of pan masala or a decrease in the awareness among the public of the danger of chewing pan masala.
An analysis of rate and factors affecting malignant. Oral submucous fibrosistreatment with hyalase the journal. After a fiveyear followup ascertaining oral cancer development through linkage to the national cancer registry. Activation of yap induced endothelialmesenchymal transition endmt is an iimportant. Etiopathogenesis and management of oral submucous fibrosis. Patients who chew betel nut or tobacco often have severe submucous fibrosis and are unable to fully open their mouths. Oral submucous fibrosis current concepts in etiopathogenesis. Page 1 of 7 page number not for citation purposes lipids in health and disease. It is suggested that submucous fibrosis should be regarded as a condition that causes predisposition to the development of oral cancer.
Oral submucous fibrosis 31 in europe or north america. The upregulation of cystatin c in oral submucous fibrosis. Elevation of s100a4 expression in buccal mucosal fibroblasts by arecoline. Reconstructive management of the rare bilateral oral. Perspectives on areca nut with some global implications. Nov 24, 2012 oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Gupta s, reddy mvr, harinath bc, role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis, ind j clinbiochem, 19, 2004, 8. Proposed new grading of oral submucous fibrosis based on.
Oral submucous fibrosis a study of prevalence potential biomarkers. A clinical case in which the patient presented with oral submucous fibrosis along with complete edentulism and salivary gland hypo function is discussed. Yousuf a lakdawala, rida arshad and syeda maria fakhar abstract oral submucous fibrosis osmf is a debilitating precancerous condition of oral mucosa characterized by the fibrosis of oral mucosa, burning sensation in mouth, intolerance to spicy food and progression of the disease leading to limitation of mouth opening. In a small number of pulmonary fibrosis cases, its possible to identify a specific cause. Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. Oral submucous fibrosis osmf is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the. Oral submucous fibrosis a disease with malignant potential. Mechanisms of fibrosis traditional roots institute.
Fibroblastic phenotype in oral submucous fibrosis a cell. Oral submucous fibrosis causes, symptoms, treatment and. The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. It is caused as a result of addiction to harmful areca nut products with or without tobacco. Oral submucous fibrosis osmf is potentially malignant condition initially described in 1950s is commonly found in. Malignant transformation of oral submucous fibrosis in taiwan. Conclusions there are few highquality studies available and the present drug treatments are in general empirical and treat only symptoms.
Oral submucous fibrosis is a chronic disease charac. A scoring system for the early detection of oral submucous. Lack of reliable evidence for oral submucous fibrosis. Index definition history keywords pathogenesis clinical features laboratory findings classification treatment 3. Oral submucous fibrosis osf is a chronic progressive, precancerous condition of the. Oral submucous fibrosis and the role of curcumin in its. Oral submucous fibrosis, a clinically benign but potentially. Jul 24, 2018 oral submucous fibrosis osmf etiology epidemiological data and intervention studies suggest that areca nut is the main aetiological factor for osf pindbor. Osmf is a chronic condition of the oral cavity which results in permanent disability. Oral sub mucous fibrosis, areca nut, malignant transformation. Betel nut and pan are freely available in the united kingdom, and in a city such as leicester, one might expect to find 3000 cases of oral submucosal fibrosis.
Unusual complication of intralesional corticosteroid in oral submucous fibrosis patient srikanth g 1, komal s 2, jyotsna r 1 and kalyana c. There are very few reports to correlate the clinical stage to histopathological. The aims of the present study were to evaluate the frequent clinical complaints of oral submucous fibrosis osf and to develop a scoring system for early detection of. Nov 14, 2015 one such reaction of the collagen of oral mucosa to arecanut is oral submucous fibrosis. Correlation of histopathological diagnosis with habits and. After 5 years of intervention, % of the intervention group stopped or reduced their chewing habit compared to 4% in the control group.
This study evaluated the alterations in extended lipid. Malignant transformation of oral submucous fibrosis in. Are we progressing pb hebbar 1, r sheshaprasad 2, s gurudath 3, a pai 2, d sujatha 2 1 department of oral medicine and radiology, yashas dental health care centre, karnataka, india 2 department of oral medicine and radiology, the oxford dental college and hospital, karnataka, india 3 department of oral medicine and radiology, kle institute of dental sciences. Mainly in india and pakistan due to smokeless tobacco chewing of betel quid reactive but risk factor for squamous cell carcinoma early lesions show blanching, mottled, marblelike appearance. Oral submucous fibrosis is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues, well recognized for its malignant potential and is. Pdf oral lesions related to the use of commercially available tobacco gutkha is going to pose a major challenge for health care providers in india find, read and cite all the research. Treatment etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. Oral submucous fibrosis osmf is a rare chronic, debilitating premalignant condition characterised by juxtaepithelial fibrosis of the oral cavity associated with an inflammatory reaction. Osf can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. Oral submucous fibrosis osmf is a condition that was first described in the 1950s. Joshi subsequently coined the termed oral submucous fibrosis osf for the condition in 1953. Oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and. September prosthetic rehabilitation of oral submucous fibrosis patients. The pathogenesis is poorly understood and the disease is difficult to.